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KMID : 0359020130460030301
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Korean Journal of Gastrointestinal Endoscopy
2013 Volume.46 No. 3 p.301 ~ p.305
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Cronkhite-Canada Syndrome Associated with Serrated Adenoma and Malignant Polyp: A Case Report and a Literature Review of 13 Cronkhite-Canada Syndrome Cases in Korea
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Yun So-Hee
Cho Jin-Woong
Kim Ji-Woong
Kim Joong-Keun
Park Moon-Sik
Lee Na-Eun
Lee Jae-Un
Lee Young-Jae
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Abstract
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Cronkhite-Canada syndrome (CCS) is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances both in the gastrointestinal tract and in the epidermis. The pathologic finding of the polyp is usually a hamartomatous polyp of the juvenile type; however, the possibility of serrated adenoma associated malignant neoplasm was reported in some Japanese cases. Up till now in South Korea, 13 CCS cases have been reported, but there was no case accompanied by the colon cancer. We report the first case of CCS associated with malignant colon polyp and serrated adenoma in Korea. A 72-year-old male patient who complained of diarrhea and weight loss was presented with both hands and feet nail dystrophy, hyperpigmentation, and alopecia. Endoscopic examination showed numerous hamartomatous polyps from the stomach to the colon. The pathologic results confirmed colon cancer and serrated adenoma. Helicobacter pylori eradication and prednisolone was used. Thus, the authors report this case along with a literature review.
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KEYWORD
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Intestinal polyposis, Colonic neoplasms, Serrated adenoma, Helicobacter pylori
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